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Titel:

Human Validation of Genes Associated With a Murine Atherosclerotic Phenotype.

Dokumenttyp:
Journal Article; Review
Autor(en):
Pasterkamp, Gerard; van der Laan, Sander W; Haitjema, Saskia; Foroughi Asl, Hassan; Siemelink, Marten A; Bezemer, Tim; van Setten, Jessica; Dichgans, Martin; Malik, Rainer; Worrall, Bradford B; Schunkert, Heribert; Samani, Nilesh J; de Kleijn, Dominique P V; Markus, Hugh S; Hoefer, Imo E; Michoel, Tom; de Jager, Saskia C A; Björkegren, Johan L M; den Ruijter, Hester M; Asselbergs, Folkert W
Abstract:
The genetically modified mouse is the most commonly used animal model for studying the pathogenesis of atherosclerotic disease. We aimed to assess if mice atherosclerosis-related genes could be validated in human disease through examination of results from genome-wide association studies.We performed a systematic review to identify atherosclerosis-causing genes in mice and carried out gene-based association tests of their human orthologs for an association with human coronary artery disease and...     »
Zeitschriftentitel:
Arterioscler Thromb Vasc Biol
Jahr:
2016
Band / Volume:
36
Heft / Issue:
6
Seitenangaben Beitrag:
1240-6
Sprache:
eng
Volltext / DOI:
doi:10.1161/ATVBAHA.115.306958
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/27079880
Print-ISSN:
1079-5642
TUM Einrichtung:
Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert)
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