Association Between Long-term Exposure to Air Pollution and Biomarkers Related to Insulin Resistance, Subclinical Inflammation, and Adipokines.

Wolf, Kathrin; Popp, Anita; Schneider, Alexandra; Breitner, Susanne; Hampel, Regina; Rathmann, Wolfgang; Herder, Christian; Roden, Michael; Koenig, Wolfgang; Meisinger, Christa; Peters, Annette

doi:10.2337/db15-1567

journal article

Document type:: Journal Article; Article
Author(s):: Wolf, Kathrin; Popp, Anita; Schneider, Alexandra; Breitner, Susanne; Hampel, Regina; Rathmann, Wolfgang; Herder, Christian; Roden, Michael; Koenig, Wolfgang; Meisinger, Christa; Peters, Annette
Title:: Association Between Long-term Exposure to Air Pollution and Biomarkers Related to Insulin Resistance, Subclinical Inflammation, and Adipokines.
Abstract:: Insulin resistance (IR) is present long before the onset of type 2 diabetes and results not only from inherited and lifestyle factors but also likely from environmental conditions. We investigated the association between modeled long-term exposure to air pollution at residence and biomarkers related to IR, subclinical inflammation, and adipokines. Data were based on 2,944 participants of the KORA (Cooperative Health Research in the Region Augsburg) F4 study conducted in southern Germany (2006-2008). We analyzed associations between individual air pollution concentration estimated by land use regression and HOMA-IR, glucose, insulin, HbA1c, leptin, and high-sensitivity C-reactive protein levels from fasting samples using multivariable linear regression models. Effect estimates were calculated for the whole study population and subgroups of individuals who did not have diabetes, had prediabetes, or had diabetes. Among all participants, a 7.9 ?g/m(3) increment in particulate matter of <10 ?m was associated with higher HOMA-IR (15.6% [95% CI 4.0; 28.6]) and insulin (14.5% [3.6; 26.5]). Nitrogen dioxide was associated with HOMA-IR, glucose, insulin, and leptin. Effect estimates for individuals with prediabetes were much larger and highly statistically significant, whereas individuals who did not have diabetes or had diabetes showed rather weak associations. No association was seen for HbA1c level. Our results suggested an association between long-term exposure to air pollution and IR in the general population was attributable mainly to individuals with diabetes.
Journal title abbreviation:: Diabetes
Year:: 2016
Journal volume:: 65
Journal issue:: 11
Pages contribution:: 3314-3326
Language:: eng
Fulltext / DOI:: doi:10.2337/db15-1567
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/27605624
Print-ISSN:: 0012-1797
TUM Institution:: Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert)
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Lehr- und Forschungskooperationen mit den Kliniken und Instituten am Deutschen Herzzentrum Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (DHM) (Prof. Schunkert)2016