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Dokumenttyp:
Journal Article; Article
Autor(en):
Payr, Stephan; Tichy, Brigitte; Atteneder, Clemens; Michel, Marc; Tiefenboeck, Thomas; Lang, Nikolaus; Nuernberger, Sylvia; Hajdu, Stefan; Rosado-Balmayor, Elizabeth; Marlovits, Stefan; Albrecht, Christian
Titel:
Redifferentiation of aged human articular chondrocytes by combining bone morphogenetic protein-2 and melanoma inhibitory activity protein in 3D-culture.
Abstract:
Melanoma inhibitory activity (MIA) affects the differentiation to hyaline cartilage and can inhibit the osteogenic potential of bone morphogenetic protein (BMP)-2 in mesenchymal stem cells (MSC). The aim of this study was to investigate if MIA also inhibits the osteogenic potential of BMP-2 in human articular chondrocytes during redifferentiation, which may lead to a higher grade of differentiation without calcification. HAC of four female patients (mean age: 73.75 ±6.98) were seeded into 3D cul...     »
Zeitschriftentitel:
PLoS ONE
Jahr:
2017
Band / Volume:
12
Heft / Issue:
7
Seitenangaben Beitrag:
e0179729
Volltext / DOI:
doi:10.1371/journal.pone.0179729
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28704392
Print-ISSN:
1932-6203
TUM Einrichtung:
Klinik und Poliklinik für Unfallchirurgie
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