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Titel:

Dual inhibition of thrombin and activated factor X attenuates disseminated intravascular coagulation and protects organ function in a baboon model of severe Gram-negative sepsis.

Dokumenttyp:
Journal Article; Article
Autor(en):
Schöchl, Herbert; Van Griensven, Martijn; Heitmeier, Stefan; Laux, Volker; Kipman, Ulrike; Roodt, Jan; Bahrami, Soheyl; Redl, Heinz
Abstract:
Inhibition of procoagulant pathways may improve outcome in sepsis. We examined whether a dual short-acting thrombin (factor II) and factor X (FX)a inhibitor (SATI) ameliorates sepsis-induced disseminated intravascular coagulation (DIC) and is organ-protective.Escherichia coli were infused for 2 h in 22 anesthetized baboons. The control (CO) group (n = 8) received sterile isotonic solution only. In the treatment groups, SATI was administered starting 15 minutes after the end of the bacterial expo...     »
Zeitschriftentitel:
Crit Care
Jahr:
2017
Band / Volume:
21
Heft / Issue:
1
Seitenangaben Beitrag:
51
Volltext / DOI:
doi:10.1186/s13054-017-1636-y
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28288667
Print-ISSN:
1466-609X
TUM Einrichtung:
Klinik und Poliklinik für Unfallchirurgie
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