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Title:

A pilot trial of doxorubicin containing phosphatidyldiglycerol based thermosensitive liposomes in spontaneous feline soft tissue sarcoma

Document type:
journal article
Author(s):
Zimmermann, K; Hossann, M; Hirschberger, J; Troedson, K; Peller, M; Schneider, M; Bruhschwein, A; Meyer-Lindenberg, A; Wess, G; Wergin, M; Dorfelt, R; Knosel, T; Schwaiger, M; Baumgartner, C; Brandl, J; Schwamberger, S; Lindner, LH
Abstract:
Purpose: Doxorubicin (DOX)-loaded phosphatidyldiglycerol-based thermosensitive liposomes (DPPG(2)-TSL-DOX) combined with local hyperthermia (HT) was evaluated in cats with locally advanced spontaneous fibrosarcomas (soft tissue sarcoma [STS]). The study was designed to evaluate the safety and pharmacokinetic profile of the drug. Results from four dose-levels are reported.Methods: Eleven client-owned cats with advanced STS were enrolled. Five cats received escalating doses of 0.1-0.4mg/kg DOX (gr...     »
Journal title abbreviation:
Int J Hyperthermia
Year:
2017
Journal volume:
33
Journal issue:
2
Pages contribution:
178-190
Language:
eng
Fulltext / DOI:
doi:10.1080/02656736.2016.1230233
Print-ISSN:
0265-6736
TUM Institution:
Fakultät für Medizin (Medizindidaktik, TUMCells, ZPF, MSZ; Profs. Tschöp bis 2015)
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