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Titel:

A pilot trial of doxorubicin containing phosphatidyldiglycerol based thermosensitive liposomes in spontaneous feline soft tissue sarcoma.

Dokumenttyp:
Journal Article
Autor(en):
Zimmermann, Katja; Hossann, Martin; Hirschberger, Johannes; Troedson, Karin; Peller, Michael; Schneider, Moritz; Brühschwein, Andreas; Meyer-Lindenberg, Andrea; Wess, Gerhard; Wergin, Melanie; Dörfelt, René; Knösel, Thomas; Schwaiger, Markus; Baumgartner, Christine; Brandl, Johanna; Schwamberger, Sabine; Lindner, Lars H
Abstract:
Doxorubicin (DOX)-loaded phosphatidyldiglycerol-based thermosensitive liposomes (DPPG-TSL-DOX) combined with local hyperthermia (HT) was evaluated in cats with locally advanced spontaneous fibrosarcomas (soft tissue sarcoma [STS]). The study was designed to evaluate the safety and pharmacokinetic profile of the drug. Results from four dose-levels are reported.Eleven client-owned cats with advanced STS were enrolled. Five cats received escalating doses of 0.1-0.4 mg/kg DOX (group I), three receiv...     »
Zeitschriftentitel:
Int J Hyperthermia
Jahr:
2017
Band / Volume:
33
Heft / Issue:
2
Seitenangaben Beitrag:
178-190
Sprache:
eng
Volltext / DOI:
doi:10.1080/02656736.2016.1230233
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/27592502
Print-ISSN:
0265-6736
TUM Einrichtung:
Klinik und Poliklinik für Nuklearmedizin; Kliniken und Institute
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