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Title:

Sevoflurane mitigates shedding of hyaluronan from the coronary endothelium, also during ischemia/reperfusion: an ex vivo animal study.

Document type:
Journal Article
Author(s):
Chen, Congcong; Chappell, Daniel; Annecke, Thorsten; Conzen, Peter; Jacob, Matthias; Welsch, Ulrich; Zwissler, Bernhard; Becker, Bernhard F
Abstract:
Glycosaminoglycan hyaluronan (HA), a major constituent of the endothelial glycocalyx, helps to maintain vascular integrity. Preconditioning the heart with volatile anesthetic agents protects against ischemia/reperfusion injury. We investigated a possible protective effect of sevoflurane on the glycocalyx, especially on HA. The effect of pre-ischemic treatment with sevoflurane (15 minutes at 2% vol/vol gas) on shedding of HA was evaluated in 28 isolated, beating guinea pig hearts, subjected to wa...     »
Journal title abbreviation:
Hypoxia (Auckl)
Year:
2016
Journal volume:
4
Pages contribution:
81-90
Language:
eng
Fulltext / DOI:
doi:10.2147/HP.S98660
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27800510
TUM Institution:
Klinik für Anästhesiologie (DHM)
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