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Titel:

Serum Amyloid A Induces Inflammation, Proliferation and Cell Death in Activated Hepatic Stellate Cells.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Siegmund, Sören V; Schlosser, Monika; Schildberg, Frank A; Seki, Ekihiro; De Minicis, Samuele; Uchinami, Hiroshi; Kuntzen, Christian; Knolle, Percy A; Strassburg, Christian P; Schwabe, Robert F
Abstract:
Serum amyloid A (SAA) is an evolutionary highly conserved acute phase protein that is predominantly secreted by hepatocytes. However, its role in liver injury and fibrogenesis has not been elucidated so far. In this study, we determined the effects of SAA on hepatic stellate cells (HSCs), the main fibrogenic cell type of the liver. Serum amyloid A potently activated I?B kinase, c-Jun N-terminal kinase (JNK), Erk and Akt and enhanced NF-?B-dependent luciferase activity in primary human and rat HS...     »
Zeitschriftentitel:
PLoS ONE
Jahr:
2016
Band / Volume:
11
Heft / Issue:
3
Seitenangaben Beitrag:
e0150893
Sprache:
eng
Volltext / DOI:
doi:10.1371/journal.pone.0150893
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/26937641
Print-ISSN:
1932-6203
TUM Einrichtung:
Roman Herzog Comprehensive Cancer Center
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