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Title:

Pancreatic Premalignant Lesions Secrete Tissue Inhibitor of Metalloproteinases-1, Which Activates Hepatic Stellate Cells Via CD63 Signaling to Create a Premetastatic Niche in the Liver.

Document type:
Journal Article; 5
Author(s):
Grünwald, Barbara; Harant, Veronika; Schaten, Susanne; Frühschütz, Monika; Spallek, Ria; Höchst, Bastian; Stutzer, Katharina; Berchtold, Sonja; Erkan, Mert; Prokopchuk, Olga; Martignoni, Marc; Esposito, Irene; Heikenwälder, Mathias; Gupta, Aayush; Siveke, Jens; Saftig, Paul; Knolle, Percy; Wohlleber, Dirk; Krüger, Achim
Abstract:
Pancreatic ductal adenocarcinoma (PDAC) metastasizes to liver at early stages, making this disease highly lethal. Tissue inhibitor of metalloproteinases-1 (TIMP1) creates a metastasis-susceptible environment in the liver. We investigated the role of TIMP1 and its receptor CD63 in metastasis of early-stage pancreatic tumors using mice and human cell lines and tissue samples.We obtained liver and plasma samples from patients in Germany with chronic pancreatitis, pancreatic intra-epithelial neoplas...     »
Journal title abbreviation:
Gastroenterology
Year:
2016
Journal volume:
151
Journal issue:
5
Pages contribution:
1011-1024.e7
Language:
eng
Fulltext / DOI:
doi:10.1053/j.gastro.2016.07.043
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27506299
Print-ISSN:
0016-5085
TUM Institution:
Chirurgische Klinik und Poliklinik; II. Medizinische Klinik und Poliklinik (Gastroenterologie); Institut für Experimentelle Onkologie und Therapieforschung; Roman Herzog Comprehensive Cancer Center
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