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Title:

Efficient and safe gene delivery to human corneal endothelium using magnetic nanoparticles.

Document type:
Journal Article; Article
Author(s):
Czugala, Marta; Mykhaylyk, Olga; Böhler, Philip; Onderka, Jasmine; Stork, Björn; Wesselborg, Sebastian; Kruse, Friedrich E; Plank, Christian; Singer, Bernhard B; Fuchsluger, Thomas A
Abstract:
To develop a safe and efficient method for targeted, anti-apoptotic gene therapy of corneal endothelial cells (CECs).Magnetofection (MF), a combination of lipofection with magnetic nanoparticles (MNPs; PEI-Mag2, SO-Mag5, PalD1-Mag1), was tested in human CECs and in explanted human corneas. Effects on cell viability and function were investigated. Immunocompatibility was assessed in human peripheral blood mononuclear cells.Silica iron-oxide MNPs (SO-Mag5) combined with X-tremeGENE-HP achieved hi...     »
Journal title abbreviation:
Nanomedicine (Lond)
Year:
2016
Journal volume:
11
Journal issue:
14
Pages contribution:
1787-800
Language:
eng
Fulltext / DOI:
doi:10.2217/nnm-2016-0144
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27388974
Print-ISSN:
1743-5889
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung
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