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Titel:

Longitudinal Assessment of Lung Cancer Progression in Mice Using the Sodium Iodide Symporter Reporter Gene and SPECT/CT Imaging.

Dokumenttyp:
Journal Article
Autor(en):
Price, Dominique N; McBride, Amber A; Anton, Martina; Kusewitt, Donna F; Norenberg, Jeffrey P; MacKenzie, Debra A; Thompson, Todd A; Muttil, Pavan
Abstract:
Lung cancer has the highest mortality rate of any tissue-specific cancer in both men and women. Research continues to investigate novel drugs and therapies to mitigate poor treatment efficacy, but the lack of a good descriptive lung cancer animal model for preclinical drug evaluation remains an obstacle. Here we describe the development of an orthotopic lung cancer animal model which utilizes the human sodium iodide symporter gene (hNIS; SLC5A5) as an imaging reporter gene for the purpose of no...     »
Zeitschriftentitel:
PLoS ONE
Jahr:
2016
Band / Volume:
11
Heft / Issue:
12
Seitenangaben Beitrag:
e0169107
Sprache:
eng
Volltext / DOI:
doi:10.1371/journal.pone.0169107
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28036366
Print-ISSN:
1932-6203
TUM Einrichtung:
Institut für Experimentelle Onkologie und Therapieforschung
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