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Title:

Transcript-activated collagen matrix as sustained mRNA delivery system for bone regeneration.

Document type:
Journal Article
Author(s):
Badieyan, Zohreh Sadat; Berezhanskyy, Taras; Utzinger, Maximilian; Aneja, Manish Kumar; Emrich, Daniela; Erben, Reinhold; Schüler, Christiane; Altpeter, Philipp; Ferizi, Mehrije; Hasenpusch, Günther; Rudolph, Carsten; Plank, Christian
Abstract:
Transcript therapies using chemically modified messenger RNAs (cmRNAs) are emerging as safe and promising alternatives for gene and recombinant protein therapies. However, their applications have been limited due to transient translation and relatively low stability of cmRNAs compared to DNA. Here we show that vacuum-dried cmRNA-loaded collagen sponges, termed transcript activated matrices (TAMs), can serve as depots for sustained delivery of cmRNA. TAMs provide steady state protein production f...     »
Journal title abbreviation:
J Control Release
Year:
2016
Journal volume:
239
Pages contribution:
137-48
Language:
eng
Fulltext / DOI:
doi:10.1016/j.jconrel.2016.08.037
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27586186
Print-ISSN:
0168-3659
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung
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