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Title:

Magnetofection Enhances Adenoviral Vector-based Gene Delivery in Skeletal Muscle Cells.

Document type:
Journal Article
Author(s):
Pereyra, Andrea Soledad; Mykhaylyk, Olga; Lockhart, Eugenia Falomir; Taylor, Jackson Richard; Delbono, Osvaldo; Goya, Rodolfo Gustavo; Plank, Christian; Hereñu, Claudia Beatriz
Abstract:
The goal of magnetic field-assisted gene transfer is to enhance internalization of exogenous nucleic acids by association with magnetic nanoparticles (MNPs). This technique named magnetofection is particularly useful in difficult-to-transfect cells. It is well known that human, mouse, and rat skeletal muscle cells suffer a maturation-dependent loss of susceptibility to Recombinant Adenoviral vector (RAd) uptake. In postnatal, fully differentiated myofibers, the expression of the primary Coxsacki...     »
Journal title abbreviation:
J Nanomed Nanotechnol
Year:
2016
Journal volume:
7
Journal issue:
2
Language:
eng
Fulltext / DOI:
doi:10.4172/2157-7439.1000364
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27274908
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung
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