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Title:

A novel nonviral gene delivery tool of BMP-2 for the reconstitution of critical-size bone defects in rats.

Document type:
Journal Article
Author(s):
Kolk, Andreas; Tischer, Thomas; Koch, Christian; Vogt, Stephan; Haller, Bernhard; Smeets, Ralf; Keutzer, Kilian; Plank, Christian; Bissinger, Oliver
Abstract:
The osseointegration of bone implants, implant failure, and the bridging of critical-size bone defects are frequent clinical challenges. Deficiencies in endogenous bone healing can be resolved through the local administration of suitable recombinant growth factors (GFs). In preclinical models, gene-therapy-supported bone healing has proven promising for overcoming certain limitations of GFs. We report the dose-dependent bridging of critical-size mandibular bone defects (CSDs) in a rat model usin...     »
Journal title abbreviation:
J Biomed Mater Res A
Year:
2016
Journal volume:
104
Journal issue:
10
Pages contribution:
2441-55
Language:
eng
Fulltext / DOI:
doi:10.1002/jbm.a.35773
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27176560
Print-ISSN:
1549-3296
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung; Institut für Medizinische Statistik und Epidemiologie; Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie
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