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Title:

Longitudinal Assessment of Lung Cancer Progression in Mice Using the Sodium Iodide Symporter Reporter Gene and SPECT/CT Imaging.

Document type:
Journal Article
Author(s):
Price, Dominique N; McBride, Amber A; Anton, Martina; Kusewitt, Donna F; Norenberg, Jeffrey P; MacKenzie, Debra A; Thompson, Todd A; Muttil, Pavan
Abstract:
Lung cancer has the highest mortality rate of any tissue-specific cancer in both men and women. Research continues to investigate novel drugs and therapies to mitigate poor treatment efficacy, but the lack of a good descriptive lung cancer animal model for preclinical drug evaluation remains an obstacle. Here we describe the development of an orthotopic lung cancer animal model which utilizes the human sodium iodide symporter gene (hNIS; SLC5A5) as an imaging reporter gene for the purpose of no...     »
Journal title abbreviation:
PLoS ONE
Year:
2016
Journal volume:
11
Journal issue:
12
Pages contribution:
e0169107
Language:
eng
Fulltext / DOI:
doi:10.1371/journal.pone.0169107
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28036366
Print-ISSN:
1932-6203
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung
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