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Title:

Improvement of vascular function by magnetic nanoparticle-assisted circumferential gene transfer into the native endothelium.

Document type:
Journal Article
Author(s):
Vosen, Sarah; Rieck, Sarah; Heidsieck, Alexandra; Mykhaylyk, Olga; Zimmermann, Katrin; Plank, Christian; Gleich, Bernhard; Pfeifer, Alexander; Fleischmann, Bernd K; Wenzel, Daniela
Abstract:
Gene therapy is a promising approach for chronic disorders that require continuous treatment such as cardiovascular disease. Overexpression of vasoprotective genes has generated encouraging results in animal models, but not in clinical trials. One major problem in humans is the delivery of sufficient amounts of genetic vectors to the endothelium which is impeded by blood flow, whereas prolonged stop-flow conditions impose the risk of ischemia. In the current study we have therefore developed a s...     »
Journal title abbreviation:
J Control Release
Year:
2016
Journal volume:
241
Pages contribution:
164-173
Language:
eng
Fulltext / DOI:
doi:10.1016/j.jconrel.2016.09.024
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27667178
Print-ISSN:
0168-3659
TUM Institution:
Institut für Experimentelle Onkologie und Therapieforschung
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