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Titel:

Hes1 Controls Exocrine Cell Plasticity and Restricts Development of Pancreatic Ductal Adenocarcinoma in a Mouse Model.

Dokumenttyp:
Journal Article; Article
Autor(en):
Hidalgo-Sastre, Ana; Brodylo, Roxanne L; Lubeseder-Martellato, Clara; Sipos, Bence; Steiger, Katja; Lee, Marcel; von Figura, Guido; Grünwald, Barbara; Zhong, Suyang; Trajkovic-Arsic, Marija; Neff, Florian; Schmid, Roland M; Siveke, Jens T
Abstract:
Perturbation of pancreatic acinar cell state can lead to acinar-to-ductal metaplasia (ADM), a precursor lesion to the development of pancreatic ductal adenocarcinoma (PDAC). In the pancreas, Notch signaling is active both during development and in adult cellular differentiation processes. Hes1, a key downstream target of the Notch signaling pathway, is expressed in the centroacinar compartment of the adult pancreas as well as in both preneoplastic and malignant lesions. In this study, we used a...     »
Zeitschriftentitel:
Am J Pathol
Jahr:
2016
Band / Volume:
186
Heft / Issue:
11
Seitenangaben Beitrag:
2934-2944
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.ajpath.2016.07.025
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/27639167
Print-ISSN:
0002-9440
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Experimentelle Onkologie und Therapieforschung
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