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Titel:

Genome-wide association study in essential tremor identifies three new loci.

Dokumenttyp:
Journal Article; Article
Autor(en):
Müller, Stefanie H; Girard, Simon L; Hopfner, Franziska; Merner, Nancy D; Bourassa, Cynthia V; Lorenz, Delia; Clark, Lorraine N; Tittmann, Lukas; Soto-Ortolaza, Alexandra I; Klebe, Stephan; Hallett, Mark; Schneider, Susanne A; Hodgkinson, Colin A; Lieb, Wolfgang; Wszolek, Zbigniew K; Pendziwiat, Manuela; Lorenzo-Betancor, Oswaldo; Poewe, Werner; Ortega-Cubero, Sara; Seppi, Klaus; Rajput, Alex; Hussl, Anna; Rajput, Ali H; Berg, Daniela; Dion, Patrick A; Wurster, Isabel; Shulman, Joshua M; Srulije...     »
Abstract:
We conducted a genome-wide association study of essential tremor, a common movement disorder characterized mainly by a postural and kinetic tremor of the upper extremities. Twin and family history studies show a high heritability for essential tremor. The molecular genetic determinants of essential tremor are unknown. We included 2807 patients and 6441 controls of European descent in our two-stage genome-wide association study. The 59 most significantly disease-associated markers of the discover...     »
Zeitschriftentitel:
Brain
Jahr:
2016
Band / Volume:
139
Heft / Issue:
Pt 12
Seitenangaben Beitrag:
3163-3169
Sprache:
eng
Volltext / DOI:
doi:10.1093/brain/aww242
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/27797806
Print-ISSN:
0006-8950
TUM Einrichtung:
Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie; Lehrstuhl für Neurogenetik (Prof. Winkelmann)
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