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- Dokumenttyp:
- Journal Article
- Autor(en):
- Mündermann, Annegret; Geurts, Jeroen; Hügle, Thomas; Nickel, Thomas; Schmidt-Trucksäss, Arno; Halle, Martin; Hanssen, Henner
- Titel:
- Marathon performance but not BMI affects post-marathon pro-inflammatory and cartilage biomarkers.
- Abstract:
- We tested the hypothesis that changes in serum cartilage oligomeric matrix protein (COMP), tumour necrosis factor ? (TNF-?), interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hsCRP) concentration after regular endurance training and running a marathon race depend on body mass index (BMI) and/or on marathon performance. Blood samples were collected from 45 runners of varying BMI and running experience before and after a 10-week marathon training programme and before, immediately and 24 h after a marathon race. Serum biomarker concentrations, BMI and marathon finishing time were measured. The mean (95% confidence interval (CI)) changes from before to immediately after the marathon were COMP: 4.09 U/L (3.39-4.79 U/L); TNF-?: -1.17 mg/L (-2.58 to 0.25 mg/L); IL-6: 12.0 pg/mL (11.4-12.5 pg/mL); and hsCRP: -0.08 pg/mL (-0.14 to -0.3 pg/mL). The mean (95% CI) changes from immediately after to 24 h after the marathon were COMP: 0.35 U/L (-0.88 to 1.57 U/L); TNF-?: -0.43 mg/L (-0.99 to 0.13 mg/L); IL-6: -9.9 pg/mL (-10.5 to -9.4 pg/mL); and hsCRP: 1.52 pg/mL (1.25-1.79 pg/mL). BMI did not affect changes in biomarker concentrations. Differences in marathon finishing time explained 32% of variability in changes in serum hsCRP and 28% of variability in changes in serum COMP during the 24 h recovery after the marathon race (P < 0.001). Slower marathon finishing time but not a higher BMI modulates increases in pro-inflammatory markers or cartilage markers following a marathon race.
- Zeitschriftentitel:
- J Sports Sci
- Jahr:
- 2017
- Band / Volume:
- 35
- Heft / Issue:
- 7
- Seitenangaben Beitrag:
- 711-718
- Sprache:
- eng
- Volltext / DOI:
- doi:10.1080/02640414.2016.1184301
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/27167978
- Print-ISSN:
- 0264-0414
- TUM Einrichtung:
- Poliklinik für Präventive und Rehabilitative Sportmedizin
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