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- Titel:
[Patients with prostate cancer after radical prostatectomy: Stage migration and changes in tumor characteristics from 1998-2012].
- Dokumenttyp:
- Journal Article; Article
- Autor(en):
- Walther, A; Kron, M; Klorek, T; Gschwend, J E; Herkommer, K
- Abstract:
- The aim of this study was to verify the described inverse stage migration after radical prostatectomy by a tertiary care center in 2011 in a national collective.Data from 10,323 patients with prostate cancer (PCa), who had radical prostatectomy between 1998 and 2012, were analyzed regarding prostate-specific antigen (PSA) and age at diagnosis, T stage, and Gleason score. A trend over time was determined by using the Jonckheere-Terpstra test.Median age at surgery was 65 years (1998: 63.7; 2012: 66.5). The proportion of low-risk tumors decreased from 39% in 2005 to 25% in 2012, while the intermediate-risk tumors showed a continuous increase since 1998 from 35 to 52% in 2012. The proportion of patients with a Gleason score <= 6 decreased from 60% in 1998 to 25 % in 2012. The Gleason score groups 7a and 7b, however, increased from 12 to 46, % and 12 to 19%, respectively. The proportion of tumors with a Gleason score of 8-10 decreased from 16 to 10%. The proportion of organ-confined prostate cancer increased from 1998 to 2007 continuously from 57 to 73%. Since 2007 the proportion dropped to 64%.In this national population a trend towards inverse stage migration can be noted. Both the increase in Gleason score >= 6 and intermediate-risk tumors can be explained by the modification of the Gleason score. The tendency towards higher age and nonorgan-confined cancers at surgery could be dependent of the growing recognition of radical prostatectomy as a treatment for locally advanced prostate cancer, on the one hand, and the increase of alternative treatments for low-risk cancers, on the other hand.
- Zeitschriftentitel:
- Urologe A
- Jahr:
- 2016
- Band / Volume:
- 55
- Heft / Issue:
- 2
- Seitenangaben Beitrag:
- 167-75
- Sprache:
- de
- Volltext / DOI:
- doi:10.1007/s00120-015-3988-8
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/26471796
- Print-ISSN:
- 0340-2592
- TUM Einrichtung:
- Urologische Klinik und Poliklinik
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