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Titel:

The Role of PD-L1 Expression and Intratumoral Lymphocytes in Response to Perioperative Chemotherapy for Urothelial Carcinoma.

Dokumenttyp:
journal article
Autor(en):
Erlmeier, F; Seitz, A K; Hatzichristodoulou, G; Stecher, L; Retz, M; Gschwend, J E; Weichert, W; Kübler, H R; Horn, T
Abstract:
Introduction: Immunological pathways are relevant for the effectiveness of conventional cytotoxic chemotherapy. Recently, checkpoint inhibition of the PD-1/PD-L1 axis has been shown to be therapeutically relevant in urothelial carcinoma. Objective: To monitor PD-L1 expression on tumor cells and intratumoral infiltration with CD8 positive lymphocytes during perioperative chemotherapy for urothelial cancer and to evaluate their use as potential predictive markers for chemotherapy. Patients and Met...     »
Zeitschriftentitel:
Bladder Cancer
Jahr:
2016
Band / Volume:
2
Heft / Issue:
4
Seitenangaben Beitrag:
425-432
Sprache:
eng
Volltext / DOI:
doi:10.3233/BLC-160067
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28035323
Print-ISSN:
2352-3727
TUM Einrichtung:
Institut für Allgemeine Pathologie und pathologische Anatomie; Urologische Klinik und Poliklinik
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