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Title:

Roquin Paralogs Differentially Regulate Functional NKT Cell Subsets.

Document type:
Journal Article; Article
Author(s):
Drees, Christoph; Vahl, J Christoph; Bortoluzzi, Sabrina; Heger, Klaus D; Fischer, Julius C; Wunderlich, F Thomas; Peschel, Christian; Schmidt-Supprian, Marc
Abstract:
NKT cells represent a small subset of glycolipid-recognizing T cells that are heavily implicated in human allergic, autoimmune, and malignant diseases. In the thymus, precursor cells recognize self-glycolipids by virtue of their semi-invariant TCR, which triggers NKT cell lineage commitment and maturation. During their development, NKT cells are polarized into the NKT1, NKT2, and NKT17 subsets, defined through their cytokine-secretion patterns and the expression of key transcription factors. How...     »
Journal title abbreviation:
J Immunol
Year:
2017
Journal volume:
198
Journal issue:
7
Pages contribution:
2747-2759
Language:
eng
Fulltext / DOI:
doi:10.4049/jimmunol.1601732
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28188245
Print-ISSN:
0022-1767
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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