User: Guest  Login
Title:

Polycomb protein RING1A limits hematopoietic differentiation in myelodysplastic syndromes.

Document type:
Journal Article; Article
Author(s):
Palau, Anna; Garz, Anne-Kathrin; Diesch, Jeannine; Zwick, Anabel; Malinverni, Roberto; Valero, Vanesa; Lappin, Katrina; Casquero, Raquel; Lennartsson, Andreas; Zuber, Johannes; Navarro, Tomàs; Mills, Ken I; Götze, Katharina S; Buschbeck, Marcus
Abstract:
Genetic lesions affecting epigenetic regulators are frequent in myelodysplastic syndromes (MDS). Polycomb proteins are key epigenetic regulators of differentiation and stemness that act as two multimeric complexes termed polycomb repressive complexes 1 and 2, PRC1 and PRC2, respectively. While components and regulators of PRC2 such as ASXL1 and EZH2 are frequently mutated in MDS and AML, little is known about the role of PRC1. To analyze the role of PRC1, we have taken a functional approach test...     »
Journal title abbreviation:
Oncotarget
Year:
2017
Journal volume:
8
Journal issue:
70
Pages contribution:
115002-115017
Language:
eng
Fulltext / DOI:
doi:10.18632/oncotarget.22839
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29383137
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
 BibTeX