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Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Jespersen, Henrik; Lindberg, Mattias F; Donia, Marco; Söderberg, Elin M V; Andersen, Rikke; Keller, Ulrich; Ny, Lars; Svane, Inge Marie; Nilsson, Lisa M; Nilsson, Jonas A
Title:
Clinical responses to adoptive T-cell transfer can be modeled in an autologous immune-humanized mouse model.
Abstract:
Immune checkpoint inhibitors and adoptive cell transfer (ACT) of autologous tumor-infiltrating T cells have shown durable responses in patients with melanoma. To study ACT and immunotherapies in a humanized model, we have developed PDXv2.0 - a melanoma PDX model where tumor cells and tumor-infiltrating T cells from the same patient are transplanted sequentially in non-obese diabetic/severe combined immune-deficient/common gamma chain (NOG/NSG) knockout mouse. Key to T-cell survival/effect in thi...     »
Journal title abbreviation:
Nat Commun
Year:
2017
Journal volume:
8
Journal issue:
1
Pages contribution:
707
Language:
eng
Fulltext / DOI:
doi:10.1038/s41467-017-00786-z
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28955032
Print-ISSN:
2041-1723
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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