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Title:

[Lu]pentixather: Comprehensive Preclinical Characterization of a First CXCR4-directed Endoradiotherapeutic Agent.

Document type:
Journal Article; Article
Author(s):
Schottelius, Margret; Osl, Theresa; Poschenrieder, Andreas; Hoffmann, Frauke; Beykan, Seval; Hänscheid, Heribert; Schirbel, Andreas; Buck, Andreas K; Kropf, Saskia; Schwaiger, Markus; Keller, Ulrich; Lassmann, Michael; Wester, Hans-Jürgen
Abstract:
Based on the clinical relevance of the chemokine receptor 4 (CXCR4) as a molecular target in cancer and on the success of [Ga]pentixafor as an imaging probe for high-contrast visualization of CXCR4-expression, the spectrum of clinical CXCR4-targeting was expanded towards peptide receptor radionuclide therapy (PRRT) by the development of [Lu]pentixather. CXCR4 affinity, binding specificity, hCXCR4 selectivity and internalization efficiency of [Lu]pentixather were evaluated using different human...     »
Journal title abbreviation:
Theranostics
Year:
2017
Journal volume:
7
Journal issue:
9
Pages contribution:
2350-2362
Language:
eng
Fulltext / DOI:
doi:10.7150/thno.19119
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28744319
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Klinik und Poliklinik für Nuklearmedizin
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