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- Title:
Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding.
- Document type:
- Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Article
- Author(s):
- Kim, Jae Geun; Suyama, Shigetomo; Koch, Marco; Jin, Sungho; Argente-Arizon, Pilar; Argente, Jesús; Liu, Zhong-Wu; Zimmer, Marcelo R; Jeong, Jin Kwon; Szigeti-Buck, Klara; Gao, Yuanqing; García-Cáceres, Cristina; Yi, Chun-Xia; Salmaso, Natalina; Vaccarino, Flora M; Chowen, Julie; Diano, Sabrina; Dietrich, Marcelo O; Tschöp, Matthias H; Horvath, Tamas L
- Abstract:
- We found that leptin receptors were expressed in hypothalamic astrocytes and that their conditional deletion led to altered glial morphology and synaptic inputs onto hypothalamic neurons involved in feeding control. Leptin-regulated feeding was diminished, whereas feeding after fasting or ghrelin administration was elevated in mice with astrocyte-specific leptin receptor deficiency. These data reveal an active role of glial cells in hypothalamic synaptic remodeling and control of feeding by lept... »
- Journal title abbreviation:
- Nat Neurosci
- Year:
- 2014
- Journal volume:
- 17
- Journal issue:
- 7
- Pages contribution:
- 908-10
- Language:
- eng
- Fulltext / DOI:
- doi:10.1038/nn.3725
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/24880214
- Print-ISSN:
- 1097-6256
- TUM Institution:
- Kliniken und Institute
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