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Title:

p62 links ?-adrenergic input to mitochondrial function and thermogenesis.

Document type:
Journal Article; Article
Author(s):
Müller, Timo D; Lee, Sang Jun; Jastroch, Martin; Kabra, Dhiraj; Stemmer, Kerstin; Aichler, Michaela; Abplanalp, Bill; Ananthakrishnan, Gayathri; Bhardwaj, Nakul; Collins, Sheila; Divanovic, Senad; Endele, Max; Finan, Brian; Gao, Yuanqing; Habegger, Kirk M; Hembree, Jazzmin; Heppner, Kristy M; Hofmann, Susanna; Holland, Jenna; Küchler, Daniela; Kutschke, Maria; Krishna, Radha; Lehti, Maarit; Oelkrug, Rebecca; Ottaway, Nickki; Perez-Tilve, Diego; Raver, Christine; Walch, Axel K; Schriever, Sonja C...     »
Abstract:
The scaffold protein p62 (sequestosome 1; SQSTM1) is an emerging key molecular link among the metabolic, immune, and proliferative processes of the cell. Here, we report that adipocyte-specific, but not CNS-, liver-, muscle-, or myeloid-specific p62-deficient mice are obese and exhibit a decreased metabolic rate caused by impaired nonshivering thermogenesis. Our results show that p62 regulates energy metabolism via control of mitochondrial function in brown adipose tissue (BAT). Accordingly, ad...     »
Journal title abbreviation:
J Clin Invest
Year:
2013
Journal volume:
123
Journal issue:
1
Pages contribution:
469-78
Language:
eng
Fulltext / DOI:
doi:10.1172/JCI64209
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/23257354
Print-ISSN:
0021-9738
TUM Institution:
Kliniken und Institute
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