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Title:

Ghrelin-induced food intake and adiposity depend on central mTORC1/S6K1 signaling.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Stevanovic, Darko; Trajkovic, Vladimir; Müller-Lühlhoff, Sabrina; Brandt, Elisabeth; Abplanalp, William; Bumke-Vogt, Christiane; Liehl, Beate; Wiedmer, Petra; Janjetovic, Kristina; Starcevic, Vesna; Pfeiffer, Andreas F H; Al-Hasani, Hadi; Tschöp, Matthias H; Castañeda, Tamara R
Abstract:
Signaling through the mammalian target of rapamycin complex 1 (mTORC1) and its effectors the S6-kinases (S6K) in the hypothalamus is thought to be involved in nutrient sensing and control of food intake. Given the anatomical proximity of this pathway to circuits for the hormone ghrelin, we investigated the potential role of the mTORC1/S6K pathway in mediating the metabolic effects of ghrelin. We found that ghrelin promoted phosphorylation of S6K1 in the mouse hypothalamic cell line N-41 and in t...     »
Journal title abbreviation:
Mol Cell Endocrinol
Year:
2013
Journal volume:
381
Journal issue:
1-2
Pages contribution:
280-90
Language:
eng
Fulltext / DOI:
doi:10.1016/j.mce.2013.08.009
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/23994018
Print-ISSN:
0303-7207
TUM Institution:
Kliniken und Institute
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