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Title:

The effects of vertical sleeve gastrectomy in rodents are ghrelin independent.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Chambers, Adam P; Kirchner, Henriette; Wilson-Perez, Hilary E; Willency, Jill A; Hale, John E; Gaylinn, Bruce D; Thorner, Michael O; Pfluger, Paul T; Gutierrez, Jesus A; Tschöp, Matthias H; Sandoval, Darleen A; Seeley, Randy J
Abstract:
Reductions in levels of the hunger-stimulating hormone ghrelin have been proposed to mediate part of the effects of vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass surgeries for obesity. We studied circulating levels of acyl and desacyl ghrelin in rats after these surgeries. We found that blood levels of ghrelin were reduced after VSG, but not after Roux-en-Y gastric bypass, based on enzyme-linked immunosorbent assay and mass-spectrometry analyses. We compared the effects of VSG i...     »
Journal title abbreviation:
Gastroenterology
Year:
2013
Journal volume:
144
Journal issue:
1
Pages contribution:
50-52.e5
Language:
eng
Fulltext / DOI:
doi:10.1053/j.gastro.2012.09.009
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22995675
Print-ISSN:
0016-5085
TUM Institution:
Kliniken und Institute
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