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Titel:

The pharmacokinetics of acyl, des-acyl, and total ghrelin in healthy human subjects.

Dokumenttyp:
Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Article
Autor(en):
Tong, Jenny; Dave, Nimita; Mugundu, Ganesh M; Davis, Harold W; Gaylinn, Bruce D; Thorner, Michael O; Tschöp, Matthias H; D'Alessio, David; Desai, Pankaj B
Abstract:
Ghrelin stimulates GH secretion and regulates energy and glucose metabolism. The two circulating isoforms, acyl (AG) and des-acyl (DAG) ghrelin, have distinct metabolic effects and are under active investigation for their therapeutic potentials. However, there is only limited data on the pharmacokinetics of AG and DAG.To evaluate key pharmacokinetic parameters of AG, DAG, and total ghrelin in healthy men and women.In study 1, AG (1, 3, and 5 ?g/kg per h) was infused over 65 min in 12 healthy (8...     »
Zeitschriftentitel:
Eur J Endocrinol
Jahr:
2013
Band / Volume:
168
Heft / Issue:
6
Seitenangaben Beitrag:
821-8
Sprache:
eng
Volltext / DOI:
doi:10.1530/EJE-13-0072
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/23482590
Print-ISSN:
0804-4643
TUM Einrichtung:
Kliniken und Institute
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