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Title:

Hypothalamic innate immune reaction in obesity.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Review; Review
Author(s):
Kälin, Stefanie; Heppner, Frank L; Bechmann, Ingo; Prinz, Marco; Tschöp, Matthias H; Yi, Chun-Xia
Abstract:
Findings from rodent and human studies show that the presence of inflammatory factors is positively correlated with obesity and the metabolic syndrome. Obesity-associated inflammatory responses take place not only in the periphery but also in the brain. The hypothalamus contains a range of resident glial cells including microglia, macrophages and astrocytes, which are embedded in highly heterogenic groups of neurons that control metabolic homeostasis. This complex neural-glia network can receive...     »
Journal title abbreviation:
Nat Rev Endocrinol
Year:
2015
Journal volume:
11
Journal issue:
6
Pages contribution:
339-51
Language:
eng
Fulltext / DOI:
doi:10.1038/nrendo.2015.48
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25824676
Print-ISSN:
1759-5029
TUM Institution:
Kliniken und Institute
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