User: Guest  Login
Title:

Brain innate immunity regulates hypothalamic arcuate neuronal activity and feeding behavior.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Article
Author(s):
Reis, Wagner L; Yi, Chun-Xia; Gao, Yuanqing; Tschöp, Mathias H; Stern, Javier E
Abstract:
Hypothalamic inflammation, involving microglia activation in the arcuate nucleus (ARC), is proposed as a novel underlying mechanism in obesity, insulin and leptin resistance. However, whether activated microglia affects ARC neuronal activity, and consequently basal and hormonal-induced food intake, is unknown. We show that lipopolysaccharide, an agonist of the toll-like receptor-4 (TLR4), which we found to be expressed in ARC microglia, inhibited the firing activity of the majority of orexigenic...     »
Journal title abbreviation:
Endocrinology
Year:
2015
Journal volume:
156
Journal issue:
4
Pages contribution:
1303-15
Language:
eng
Fulltext / DOI:
doi:10.1210/en.2014-1849
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25646713
Print-ISSN:
0013-7227
TUM Institution:
Kliniken und Institute
 BibTeX