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Title:

Effect of Deletion of Ghrelin-O-Acyltransferase on the Pulsatile Release of Growth Hormone in Mice.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Xie, T Y; Ngo, S T; Veldhuis, J D; Jeffery, P L; Chopin, L K; Tschöp, M; Waters, M J; Tolle, V; Epelbaum, J; Chen, C; Steyn, F J
Abstract:
Ghrelin, a gut hormone originating from the post-translational cleavage of preproghrelin, is the endogenous ligand of growth hormone secretagogue receptor 1a (GHS-R1a). Within the growth hormone (GH) axis, the biological activity of ghrelin requires octanoylation by ghrelin-O-acyltransferase (GOAT), conferring selective binding to the GHS-R1a receptor via acylated ghrelin. Complete loss of preproghrelin-derived signalling (through deletion of the Ghrl gene) contributes to a decline in peak GH re...     »
Journal title abbreviation:
J Neuroendocrinol
Year:
2015
Journal volume:
27
Journal issue:
12
Pages contribution:
872-86
Language:
eng
Fulltext / DOI:
doi:10.1111/jne.12327
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26442444
Print-ISSN:
0953-8194
TUM Institution:
Kliniken und Institute
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