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Title:

Inverse agonistic action of 3-iodothyronamine at the human trace amine-associated receptor 5.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Dinter, Juliane; Mühlhaus, Jessica; Wienchol, Carolin Leonie; Yi, Chun-Xia; Nürnberg, Daniela; Morin, Silke; Grüters, Annette; Köhrle, Josef; Schöneberg, Torsten; Tschöp, Matthias; Krude, Heiko; Kleinau, Gunnar; Biebermann, Heike
Abstract:
Application of 3-iodothyronamine (3-T1AM) results in decreased body temperature and body weight in rodents. The trace amine-associated receptor (TAAR) 1, a family A G protein-coupled receptor, is a target of 3-T1AM. However, 3-T1AM effects still persist in mTaar1 knockout mice, which suggest so far unknown further receptor targets that are of physiological relevance. TAAR5 is a highly conserved TAAR subtype among mammals and we here tested TAAR5 as a potential 3-T1AM target. First, we investigat...     »
Journal title abbreviation:
PLoS ONE
Year:
2015
Journal volume:
10
Journal issue:
2
Pages contribution:
e0117774
Language:
eng
Fulltext / DOI:
doi:10.1371/journal.pone.0117774
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25706283
Print-ISSN:
1932-6203
TUM Institution:
Kliniken und Institute
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