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Titel:

Brain innate immunity regulates hypothalamic arcuate neuronal activity and feeding behavior.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Article
Autor(en):
Reis, Wagner L; Yi, Chun-Xia; Gao, Yuanqing; Tschöp, Mathias H; Stern, Javier E
Abstract:
Hypothalamic inflammation, involving microglia activation in the arcuate nucleus (ARC), is proposed as a novel underlying mechanism in obesity, insulin and leptin resistance. However, whether activated microglia affects ARC neuronal activity, and consequently basal and hormonal-induced food intake, is unknown. We show that lipopolysaccharide, an agonist of the toll-like receptor-4 (TLR4), which we found to be expressed in ARC microglia, inhibited the firing activity of the majority of orexigenic...     »
Zeitschriftentitel:
Endocrinology
Jahr:
2015
Band / Volume:
156
Heft / Issue:
4
Seitenangaben Beitrag:
1303-15
Sprache:
eng
Volltext / DOI:
doi:10.1210/en.2014-1849
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25646713
Print-ISSN:
0013-7227
TUM Einrichtung:
Kliniken und Institute
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