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Title:

Duodenal nutrient exclusion improves metabolic syndrome and stimulates villus hyperplasia.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Article
Author(s):
Habegger, Kirk M; Al-Massadi, Omar; Heppner, Kristy M; Myronovych, Andriy; Holland, Jenna; Berger, Jose; Yi, Chun-Xia; Gao, Yuanging; Lehti, Maarit; Ottaway, Nickki; Amburgy, Sarah; Raver, Christine; Müller, Timo D; Pfluger, Paul T; Kohli, Rohit; Perez-Tilve, Diego; Seeley, Randy J; Tschöp, Matthias H
Abstract:
Surgical interventions that prevent nutrient exposure to the duodenum are among the most successful treatments for obesity and diabetes. However, these interventions are highly invasive, irreversible and often carry significant risk. The duodenal-endoluminal sleeve (DES) is a flexible tube that acts as a barrier to nutrient-tissue interaction along the duodenum. We implanted this device in Zucker Diabetic Fatty (ZDF) rats to gain greater understanding of duodenal nutrient exclusion on glucose ho...     »
Journal title abbreviation:
Gut
Year:
2014
Journal volume:
63
Journal issue:
8
Pages contribution:
1238-46
Language:
eng
Fulltext / DOI:
doi:10.1136/gutjnl-2013-304583
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24107591
Print-ISSN:
0017-5749
TUM Institution:
Kliniken und Institute
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