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Title:

Acute administration of unacylated ghrelin has no effect on Basal or stimulated insulin secretion in healthy humans.

Document type:
Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.; Article
Author(s):
Tong, Jenny; Davis, Harold W; Summer, Suzanne; Benoit, Stephen C; Haque, Ahrar; Bidlingmaier, Martin; Tschöp, Matthias H; D'Alessio, David
Abstract:
Unacylated ghrelin (UAG) is the predominant ghrelin isoform in the circulation. Despite its inability to activate the classical ghrelin receptor, preclinical studies suggest that UAG may promote ?-cell function. We hypothesized that UAG would oppose the effects of acylated ghrelin (AG) on insulin secretion and glucose tolerance. AG (1 µg/kg/h), UAG (4 µg/kg/h), combined AG+UAG, or saline were infused to 17 healthy subjects (9 men and 8 women) on four occasions in randomized order. Ghrelin was in...     »
Journal title abbreviation:
Diabetes
Year:
2014
Journal volume:
63
Journal issue:
7
Pages contribution:
2309-19
Language:
eng
Fulltext / DOI:
doi:10.2337/db13-1598
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24550190
Print-ISSN:
0012-1797
TUM Institution:
Kliniken und Institute
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