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Titel:

GLP-1R responsiveness predicts individual gastric bypass efficacy on glucose tolerance in rats.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Article
Autor(en):
Habegger, Kirk M; Heppner, Kristy M; Amburgy, Sarah E; Ottaway, Nickki; Holland, Jenna; Raver, Christine; Bartley, Erin; Müller, Timo D; Pfluger, Paul T; Berger, Jose; Toure, Mouhamadoul; Benoit, Stephen C; DiMarchi, Richard D; Perez-Tilve, Diego; D'Alessio, David A; Seeley, Randy J; Tschöp, Matthias H
Abstract:
Several bariatric operations are currently used to treat obesity and obesity-related comorbidities. These vary in efficacy, but most are more effective than current pharmaceutical treatments. Roux-en-Y gastric bypass (RYGB) produces substantial body weight (BW) loss and enhanced glucose tolerance, and is associated with increased secretion of the gut hormone glucagon-like peptide 1 (GLP-1). Given the success of GLP-1-based agents in lowering blood glucose levels and BW, we hypothesized that an i...     »
Zeitschriftentitel:
Diabetes
Jahr:
2014
Band / Volume:
63
Heft / Issue:
2
Seitenangaben Beitrag:
505-13
Sprache:
eng
Volltext / DOI:
doi:10.2337/db13-0511
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24186863
Print-ISSN:
0012-1797
TUM Einrichtung:
Kliniken und Institute
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