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Titel:

Accomplices of the Hypoxic Tumor Microenvironment Compromising Antitumor Immunity: Adenosine, Lactate, Acidosis, Vascular Endothelial Growth Factor, Potassium Ions, and Phosphatidylserine.

Dokumenttyp:
Journal Article; Review
Autor(en):
Vaupel, Peter; Multhoff, Gabriele
Abstract:
In this minireview, we aim to highlight key factors of the tumor microenvironment, including adenosine, lactate, acidosis, vascular endothelial growth factor, phosphatidylserine, high extracellular K+ levels, and tumor hypoxia with respect to antitumor immune functions. Most solid tumors have an immature chaotic microvasculature that results in tumor hypoxia. Hypoxia is a key determinant of tumor aggressiveness and therapy resistance and hypoxia-related gene products can thwart antitumor immune...     »
Zeitschriftentitel:
Front Immunol
Jahr:
2017
Band / Volume:
8
Seitenangaben Beitrag:
1887
Sprache:
eng
Volltext / DOI:
doi:10.3389/fimmu.2017.01887
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29312351
Print-ISSN:
1664-3224
TUM Einrichtung:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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