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Titel:

The Hsp70 inhibiting peptide aptamer A17 potentiates radiosensitization of tumor cells by Hsp90 inhibition.

Dokumenttyp:
Journal Article; Article
Autor(en):
Schilling, Daniela; Garrido, Carmen; Combs, Stephanie E; Multhoff, Gabriele
Abstract:
The inhibition of heat shock protein 90 (Hsp90) is a promising strategy to increase the radiosensitivity of tumor cells. However, Hsp90 inhibition induces the expression of Hsp70 which is a prominent cytoprotective protein. Therefore, dual targeting of Hsp70 and Hsp90 might be beneficial to increase the radiosensitivity of tumor cells. Hsp70 inhibiting peptide aptamers have been shown to increase the sensitivity of tumor cells to apoptosis induced by different anticancer drugs. Herein, we studie...     »
Zeitschriftentitel:
Cancer Lett
Jahr:
2017
Band / Volume:
390
Seitenangaben Beitrag:
146-152
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.canlet.2017.01.015
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28108313
Print-ISSN:
0304-3835
TUM Einrichtung:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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