[PSMA-radioguided surgery in localized recurrent prostate cancer : Current and future aspects].

Rauscher, I; Eiber, M; Jilg, C A; Gschwend, J E; Maurer, T

doi:10.1007/s00120-016-0275-2

2017

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Title:: [PSMA-radioguided surgery in localized recurrent prostate cancer : Current and future aspects].
Document type:: Journal Article; Review; Article
Author(s):: Rauscher, I; Eiber, M; Jilg, C A; Gschwend, J E; Maurer, T
Abstract:: Recently, PSMA-radioguided surgery (PSMA-RGS) was introduced for targeted resection of localized prostate cancer recurrence. Prerequisite for preoperative patient selection and localization of tumor recurrence is a positive Ga-HBED-CC PSMA positron emission tomography (PET) scan with preferably only singular soft tissue or lymph node recurrence. After injection of In-PSMA I&T or Tc-PSMA-I&S single photon emission computer tomography (SPECT)/computer tomography (CT) examination is performed in every patient to verify radiotracer uptake in tumor lesions. In a preliminary study, In-PSMA I&T SPECT/CT could detect about half of the Ga-HBED-CC PSMA PET-positive lesions, while nearly all PET-positive lesions could be detected using PSMA-RGS and also five additional lesions compared to Ga-HBED-CC-PSMA PET. Follow-up data from 55 patients show a PSA reduction >50% and >90% in 44 (80%) and 29 (53%) patients, respectively. In 34 (62%) patients, a PSA drop to <0.2 ng/ml was observed. In all, 15 (27%) patients received further PC-specific treatment; the remaining 40 (73%) patients did not undergo further treatment. In 33% of patients, surgery-related complications were noted; however, most were regarded as minor. Thus, PSMA-RGS seems to be of high value in patients with localized prostate cancer recurrence with exact localization and resection of metastatic tissue. However, patient selection based on Ga-PSMA PET imaging and clinical parameters is crucial to obtain satisfactory oncological results.
Journal title abbreviation:: Urologe A
Year:: 2017
Journal volume:: 56
Journal issue:: 1
Pages contribution:: 18-23
Language:: de
Fulltext / DOI:: doi:10.1007/s00120-016-0275-2
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/27885455
Print-ISSN:: 0340-2592
TUM Institution:: Klinik und Poliklinik für Nuklearmedizin; Urologische Klinik und Poliklinik
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Klinik und Poliklinik für Urologie (Prof. Gschwend)2017

mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Klinik und Poliklinik für Nuklearmedizin (Prof. Weber)2017