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Title:

Individual Correspondence of Amyloid-? and Intrinsic Connectivity in the Posterior Default Mode Network Across Stages of Alzheimer's Disease.

Document type:
Journal Article
Author(s):
Pasquini, Lorenzo; Benson, Gloria; Grothe, Michel J; Utz, Lukas; Myers, Nicholas E; Yakushev, Igor; Grimmer, Timo; Scherr, Martin; Sorg, Christian
Abstract:
In Alzheimer's disease (AD), amyloid-? (A?) pathology and intrinsic functional connectivity (iFC) interact. Across stages of AD, we expected individual spatial correspondence of A? and iFC to reveal both A? accumulation and its detrimental effects on iFC. We used resting-state functional magnetic imaging and A? imaging in a cross-sectional sample of 90 subjects across stages of AD and healthy older adults. Global and local correspondence of A? and iFC were assessed within the posterior default m...     »
Journal title abbreviation:
J Alzheimers Dis
Year:
2017
Journal volume:
58
Journal issue:
3
Pages contribution:
763-773
Language:
eng
Fulltext / DOI:
doi:10.3233/JAD-170096
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28482640
Print-ISSN:
1387-2877
TUM Institution:
Klinik und Poliklinik für Nuklearmedizin; Klinik und Poliklinik für Psychiatrie und Psychotherapie
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