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Titel:

?- Versus ?-Emitting Radionuclides for Pretargeted Radioimmunotherapy of Carcinoembryonic Antigen-Expressing Human Colon Cancer Xenografts.

Dokumenttyp:
Comparative Study; Journal Article; Article
Autor(en):
Heskamp, Sandra; Hernandez, Reinier; Molkenboer-Kuenen, Janneke D M; Essler, Markus; Bruchertseifer, Frank; Morgenstern, Alfred; Steenbergen, Erik J; Cai, Weibo; Seidl, Christof; McBride, William J; Goldenberg, David M; Boerman, Otto C
Abstract:
Pretargeted radioimmunotherapy (PRIT) with the ?-emitting radionuclide Lu is an attractive approach to treat carcinoembryonic antigen (CEA)-expressing tumors. The therapeutic efficacy of PRIT might be improved using ?-emitting radionuclides such as Bi. Herein, we report and compare the tumor-targeting properties and therapeutic efficacy of Bi and Lu for PRIT of CEA-expressing xenografts, using the bispecific monoclonal antibody TF2 (anti-CEA × anti-histamine-succinyl-glycine [HSG]) and the di-HS...     »
Zeitschriftentitel:
J Nucl Med
Jahr:
2017
Band / Volume:
58
Heft / Issue:
6
Seitenangaben Beitrag:
926-933
Sprache:
eng
Volltext / DOI:
doi:10.2967/jnumed.116.187021
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28232604
Print-ISSN:
0161-5505
TUM Einrichtung:
Klinik und Poliklinik für Nuklearmedizin
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