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Title:

Susceptible genes and disease mechanisms identified in frontotemporal dementia and frontotemporal dementia with Amyotrophic Lateral Sclerosis by DNA-methylation and GWAS.

Document type:
journal article
Author(s):
Taskesen, E; Mishra, A; van der Sluis, S; Ferrari, R; International FTD-Genomics Consortium; Veldink, J H; van Es, M A; Smit, A B; Posthuma, D; Pijnenburg, Y; Hernandez, D G; Nalls, M A; Rohrer, J D; Ramasamy, A; Kwok, J B J; Dobson-Stone, C; Schofield, P R; Halliday, G M; Hodges, J R; Piguet, O; Bartley, L; Thompson, E; Haan, E; Hernández, I; Ruiz, A; Boada, M; Borroni, B; Padovani, A; Cruchaga, C; Cairns, N J; Benussi, L; Binetti, G; Ghidoni, R; Forloni, G; Albani, D; Galimberti, D; Fenoglio,...     »
Abstract:
Frontotemporal dementia (FTD) is a neurodegenerative disorder predominantly affecting the frontal and temporal lobes. Genome-wide association studies (GWAS) on FTD identified only a few risk loci. One of the possible explanations is that FTD is clinically, pathologically, and genetically heterogeneous. An important open question is to what extent epigenetic factors contribute to FTD and whether these factors vary between FTD clinical subgroup. We compared the DNA-methylation levels of FTD cases...     »
Journal title abbreviation:
Sci Rep
Year:
2017
Journal volume:
7
Journal issue:
1
Pages contribution:
8899
Language:
eng
Fulltext / DOI:
doi:10.1038/s41598-017-09320-z
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28827549
TUM Institution:
Klinik und Poliklinik für Psychiatrie und Psychotherapie
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