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Titel:

Tryptase potentiates enteric nerve activation by histamine and serotonin: Relevance for the effects of mucosal biopsy supernatants from irritable bowel syndrome patients.

Dokumenttyp:
Journal Article
Autor(en):
Ostertag, D; Annahazi, A; Krueger, D; Michel, K; Demir, I E; Ceyhan, G O; Zeller, F; Schemann, M
Abstract:
We previously showed that mucosal biopsy supernatants from irritable bowel syndrome patients activated neurons despite low concentrations of tryptase, histamine, and serotonin which individually would not cause spike discharge. We studied the potentiating responses between these mediators on excitability of enteric neurons.Calcium-imaging was performed using the calcium-sensitive dye Fluo-4 AM in human submucous plexus preparations from 45 individuals. Histamine, serotonin, and tryptase were app...     »
Zeitschriftentitel:
Neurogastroenterol Motil
Jahr:
2017
Band / Volume:
29
Heft / Issue:
9
Sprache:
eng
Volltext / DOI:
doi:10.1111/nmo.13070
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28374503
Print-ISSN:
1350-1925
TUM Einrichtung:
Chirurgische Klinik und Poliklinik
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