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Title:

Co-ordinated overexpression of SIRT1 and STAT3 is associated with poor survival outcome in gastric cancer patients.

Document type:
Journal Article
Author(s):
Zhang, Shu; Huang, Shuling; Deng, Chao; Cao, Yu; Yang, Jun; Chen, Guangxia; Zhang, Bin; Duan, Chaoqin; Shi, Jiong; Kong, Bo; Friess, Helmut; Zhao, Nanyi; Huang, Chen; Huang, Xiaoli; Wang, Lei; Zou, Xiaoping
Abstract:
In many gastric cancer patients, the disease is diagnosed in an advanced stage and therefore the mortality levels are high. Because there is a need to identify novel early diagnostic and prognostic biomarkers, we tested whether SIRT1 and STAT3 are good candidates. Towards this, we used patient tissues representing different stages of gastric cancer including gastric pre-cancerous lesions, early gastric cancer, and advanced gastric cancer, and probed SIRT1, STAT3 and phosphorylated STAT3 (pSTAT3)...     »
Journal title abbreviation:
Oncotarget
Year:
2017
Journal volume:
8
Journal issue:
12
Pages contribution:
18848-18860
Language:
eng
Fulltext / DOI:
doi:10.18632/oncotarget.14473
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28061480
TUM Institution:
Chirurgische Klinik und Poliklinik
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