In this study, we collected end-expiratory breath gas samples during a 75-g OGTT in 49 women with a history of gestational diabetes mellitus (GDM). Aim was to detect a reasonable set of exhaled VOCs (volatile organic compounds) that correlate with type 2 diabetes (T2D) risk parameters allowing early diagnosis of the disease. In total, 14 out of 34 VOCs showed correlations with T2D risk parameters such as C-peptide and insulin sensitivity. However, our data do not support that breath gas analysis is sufficient for early T2D diagnosis to date. Optimization of the methodology is needed for transition into clinical practice.
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In this study, we collected end-expiratory breath gas samples during a 75-g OGTT in 49 women with a history of gestational diabetes mellitus (GDM). Aim was to detect a reasonable set of exhaled VOCs (volatile organic compounds) that correlate with type 2 diabetes (T2D) risk parameters allowing early diagnosis of the disease. In total, 14 out of 34 VOCs showed correlations with T2D risk parameters such as C-peptide and insulin sensitivity. However, our data do not support that breath gas analysis...
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