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Titel:

Mitochondrial Dysfunction Due to Lack of Manganese Superoxide Dismutase Promotes Hepatocarcinogenesis.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Konzack, Anja; Jakupovic, Mirza; Kubaichuk, Kateryna; Görlach, Agnes; Dombrowski, Frank; Miinalainen, Ilkka; Sormunen, Raija; Kietzmann, Thomas
Abstract:
One of the cancer hallmarks is mitochondrial dysfunction associated with oxidative stress. Among the first line of defense against oxidative stress is the dismutation of superoxide radicals, which in the mitochondria is carried out by manganese superoxide dismutase (MnSOD). Accordingly, carcinogenesis would be associated with a dysregulation in MnSOD expression. However, the association studies available so far are conflicting, and no direct proof concerning the role of MnSOD as a tumor promoter...     »
Zeitschriftentitel:
Antioxid Redox Signal
Jahr:
2015
Band / Volume:
23
Heft / Issue:
14
Seitenangaben Beitrag:
1059-75
Sprache:
eng
Volltext / DOI:
doi:10.1089/ars.2015.6318
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/26422659
Print-ISSN:
1523-0864
TUM Einrichtung:
Klinik für Kinderkardiologie und angeborene Herzfehler (Prof. Hess)
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