Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease.

Lu, X; Wang, L; Chen, S; He, L; Yang, X; Shi, Y; Cheng, J; Zhang, L; Gu, CC; Huang, J; Wu, T; Ma, Y; Li, J; Cao, J; Chen, J; Ge, D; Fan, Z; Li, Y; Zhao, L; Li, H; Zhou, X; Chen, L; Liu, D; Chen, J; Duan, X; Hao, Y; Wang, L; Lu, F; Liu, Z; Yao, C; Shen, C; Pu, X; Yu, L; Fang, X; Xu, L; Mu, J; Wu, X; Zheng, R; Wu, N; Zhao, Q; Li, Y; Liu, X; Wang, M; Yu, D; Hu, D; Ji, X; Guo, D; Sun, D; Wang, Q; Yang, Y; Liu, F; Mao, Q; Liang, X; Ji, J; Chen, P; Mo, X; Li, D; Chai, G; Tang, Y; Li, X; Du, Z; Liu, X; Dou, C; Yang, Z; Meng, Q; Wang, D; Wang, R; Yang, J; Schunkert, H; Samani, NJ; Kathiresan, S; Reilly, MP; Erdmann, J; Peng, X; Wu, X; Liu, D; Yang, Y; Chen, R; Qiang, B; Gu, D

doi:10.1038/ng.2337

journal article

Document type:: Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't
Author(s):: Lu, X; Wang, L; Chen, S; He, L; Yang, X; Shi, Y; Cheng, J; Zhang, L; Gu, CC; Huang, J; Wu, T; Ma, Y; Li, J; Cao, J; Chen, J; Ge, D; Fan, Z; Li, Y; Zhao, L; Li, H; Zhou, X; Chen, L; Liu, D; Chen, J; Duan, X; Hao, Y; Wang, L; Lu, F; Liu, Z; Yao, C; Shen, C; Pu, X; Yu, L; Fang, X; Xu, L; Mu, J; Wu, X; Zheng, R; Wu, N; Zhao, Q; Li, Y; Liu, X; Wang, M; Yu, D; Hu, D; Ji, X; Guo, D; Sun, D; Wang, Q; Yang, Y; Liu, F; Mao, Q; Liang, X; Ji, J; Chen, P; Mo, X; Li, D; Chai, G; Tang, Y; Li, X; Du, Z; Liu, X; Dou, C; Yang, Z; Meng, Q; Wang, D; Wang, R; Yang, J; Schunkert, H; Samani, NJ; Kathiresan, S; Reilly, MP; Erdmann, J; Peng, X; Wu, X; Liu, D; Yang, Y; Chen, R; Qiang, B; Gu, D «
Lu, X; Wang, L; Chen, S; He, L; Yang, X; Shi, Y; Cheng, J; Zhang, L; Gu, CC; Huang, J; Wu, T; Ma, Y; Li, J; Cao, J; Chen, J; Ge, D; Fan, Z; Li, Y; Zhao, L; Li, H; Zhou, X; Chen, L; Liu, D; Chen, J; Duan, X; Hao, Y; Wang, L; Lu, F; Liu, Z; Yao, C; Shen, C; Pu, X; Yu, L; Fang, X; Xu, L; Mu, J; Wu, X; Zheng, R; Wu, N; Zhao, Q; Li, Y; Liu, X; Wang, M; Yu, D; Hu, D; Ji, X; Guo, D; Sun, D; Wang, Q; Yang, Y; Liu, F; Mao, Q; Liang, X; Ji, J; Chen, P; Mo, X; Li, D; Chai, G; Tang, Y; Li, X; Du, Z; Liu, X;... »
Title:: Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease.
Abstract:: We performed a meta-analysis of 2 genome-wide association studies of coronary artery disease comprising 1,515 cases and 5,019 controls followed by replication studies in 15,460 cases and 11,472 controls, all of Chinese Han ancestry. We identify four new loci for coronary artery disease that reached the threshold of genome-wide significance (P < 5 × 10(-8)). These loci mapped in or near TTC32-WDR35, GUCY1A3, C6orf10-BTNL2 and ATP2B1. We also replicated four loci previously identified in European populations (in or near PHACTR1, TCF21, CDKN2A-CDKN2B and C12orf51). These findings provide new insights into pathways contributing to the susceptibility for coronary artery disease in the Chinese Han population.
Journal title abbreviation:: Nat Genet
Year:: 2012
Journal volume:: 44
Journal issue:: 8
Pages contribution:: 890-4
Language:: eng
Fulltext / DOI:: doi:10.1038/ng.2337
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/22751097
Print-ISSN:: 1061-4036
TUM Institution:: Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert)
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Lehr- und Forschungskooperationen mit den Kliniken und Instituten am Deutschen Herzzentrum Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (DHM) (Prof. Schunkert)2012