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Title:

The role of cytochrome P4501B1 in dibenzo[a,l]lipyrene-induced carcinogenesis

Document type:
Article; Proceedings Paper
Author(s):
Luch, A; Greim, H; Buters, JTM; Mahadevan, B; Baird, WM; Doehmer, J; Seidel, A; Glatt, H
Abstract:
In human cells, the most carcinogenic polycyclic aromatic hydrocarbon dibenzo[a,1]pyrene (DB[a,1]P) forms high levels of DNA adducts through formation of the (-)-anti-(11R,12S)-diol (13S,14R)-epoxide (DB[a,1]PDE) and its metabolic precursor, the (-)-(11R,12R)-diol. Generation of these adducts results from the catalytic activity of cytochrome P450 (P450) 1A1 and 1B1. Additional adducts such as (+)-syn-DB[a,1]PDE-DNA or more polar DNA adducts were detected only after increasing exposure doses of t...     »
Journal title abbreviation:
Polycycl Aromat Compd
Year:
2002
Journal volume:
22
Journal issue:
3-4
Pages contribution:
781-789
Language:
eng
Fulltext / DOI:
doi:10.1080/10406630290103933
Print-ISSN:
1040-6638
TUM Institution:
Molekulare Allergologie (Prof. Schmidt-Weber)
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